Unlike other similar CPAP sanitizers, the VirtuCLEAN does not require the use of a Neutralizing Pre-wash. You will find that there is no need for any other disinfectants or sanitizers when you use the VirtuCLEAN unit. You do not need soap, water, or cleaning solutions. The VirtuClean utilizes the sterilization process created by activated oxygen, otherwise known as ozone or O3. The ozone creates an environment that 99% of all life cannot exist in. If for some reason facial oil or residue were to build upon your CPAP mask, you could use facial wipes or cleaners that were approved by your particular CPAP equipment’s manufacturer.